Article
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
The Journal of clinical investigation - 1 Jun 2008
Shmelkov Sergey V, Butler Jason M, Hooper Andrea T, Hormigo Adilia, Kushner Jared, Milde Till, St Clair Ryan, Baljevic Muhamed, White Ian, Jin David K, Chadburn Amy, Murphy Andrew J, Valenzuela David M, Gale Nicholas W, Thurston Gavin, Yancopoulos George D, D'Angelica Michael, Kemeny Nancy, Lyden David, Rafii Shahin
Abstract excerpt
Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses CD133, and that only these CD133+ cancer cells are capable of tumor initiation. However, the precise contribution of CD133+ tumor-initiating cells in mediating colon cancer metastasis remains unknown. Therefore, to...
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