Article
Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis.
EBioMedicine - 1 Nov 2019
Valès Simon, Bacola Gregory, Biraud Mandy, Touvron Mélissa, Bessard Anne, Geraldo Fanny, Dougherty Kelsie A, Lashani Shaian, Bossard Céline, Flamant Mathurin, Duchalais Emilie, Marionneau-Lambot Séverine, Oullier Thibauld, Oliver Lisa, Neunlist Michel, Vallette François M, Van Landeghem Laurianne
Abstract excerpt
BACKGROUND: Colon cancer stem cells (CSCs), considered responsible for tumor initiation and cancer relapse, are constantly exposed to regulatory cues emanating from neighboring cells present in the tumor microenvironment. Among these cells are enteric glial cells (EGCs) that are potent regulators of the epithelium functions in a healthy intestine. However, whether EGCs impact CSC-driven tumorigenesis remains...
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