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Article

A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12

11 Jun 2014

Abstract excerpt

The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastatic behavior, and the majority of studies have used cloned cell lines, which do not reflect primary tumor heterogeneity. Here, we have designed a novel genome-wide screen to identify metastatic suppressors using primary human...

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Share to Cancer Cells and Metastasis
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 24920608
DOI: 10.15252/emmm.201303799

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