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Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators <i>EGR2</i> and <i>SOX2</i> in Tumorigenesis

2021-02-02

Abstract excerpt

<h4>SUMMARY</h4> Recent data support a hierarchical model of colon cancer driven by a population of cancer stem cells (CSCs). Greater understanding of the mechanisms that regulate CSCs may therefore lead to more effective treatments. Serial limiting dilution xenotransplantation assays of colon cancer patient-derived tumors demonstrated ALDH Positive cells to be enriched for tumorigenic self-renewing CSCs. In ord...

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Literature Corpus work: 83f48a66-9f16-5207-a792-5e5270a3c696
DOI: 10.1101/2021.02.02.428317

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