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Article

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.

PLoS biology - 1 Sept 2023

Hubert Christopher G, Stauffer Shaun R, Lathia Justin D

Abstract excerpt

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

Read the complete abstract on PubMed

Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Colonic Neoplasms
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Intracellular Signaling Peptides and Proteins

Share to Neoplasm Proteins

Share to Neoplastic Stem Cells

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 37713380
DOI: 10.1371/journal.pbio.3002295
PMCID: PMC10503703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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