Article
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
12 Mar 2020
Abstract excerpt
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenografts to investigate the cell of origin of metastases. We found that most disseminated CRC cells in circulation were Lgr5 − and formed distant metastases in which Lgr5 + CSCs...