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Article

SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin

30 Aug 2016

Abstract excerpt

The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance and commonly overexpressed in solid cancers including colorectal cancer. In this study, we show...

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PMID: 27571710
DOI: 10.1038/srep32350

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