Article

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

2024-04-15

Abstract excerpt

Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear. Here we report that Dickkopf-2 (DKK2) is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. Splenic injection of Dkk2 -knockout (KO) cancer organoid...

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Literature Corpus work: 76ed767b-8e59-5e7a-afcd-8175ed5844f2
DOI: 10.1101/2024.04.12.589235

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