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Article

An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.

Nature genetics - 1 Jul 2015

Han Yoon-Chi, Vidigal Joana A, Mu Ping, Yao Evelyn, Singh Irtisha, González Alvaro J, Concepcion Carla P, Bonetti Ciro, Ogrodowski Paul, Carver Brett, Selleri Licia, Betel Doron, Leslie Christina, Ventura Andrea

Abstract excerpt

Polycistronic microRNA (miRNA) clusters are a common feature of vertebrate genomes. The coordinated expression of miRNAs belonging to different seed families from a single transcriptional unit suggests functional cooperation, but this hypothesis has not been experimentally tested. Here we report the characterization of an allelic series of genetically engineered mice harboring selective targeted deletions of...

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PMID: 26029871
DOI: 10.1038/ng.3321
PMCID: PMC4485521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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