Back to search

Article

SRSF3 confers selective processing of miR-17-92 cluster to promote tumorigenic properties in colorectal cancer

2019-06-11

Abstract excerpt

Almost a half of microRNAs (miRNAs) in mammalian cells are generated from polycistronic primary transcripts encoding more than one miRNA. Mature miRNAs from polycistronic clusters frequently regulate complementary sets of target mRNAs. How the processing of individual miRNAs within the clusters is controlled to give rise to distinct miRNA levels in vivo is not fully understood. Our investigation of SRSF3 (Serine-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
09b14b8d-f60b-572a-8179-2ecb0039f325
DOI
10.1101/667295
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SRSF3 confers selective processing of miR-17-92 cluster to promote tumorigenic properties in colorectal cancerDOI 10.1101/667295
The role of SRSF3 splicing factor in generating circular RNAsSemantic proximity
Pan-Cancer Analysis Revealed SRSF9 as a New Biomarker for Prognosis and ImmunotherapySemantic proximity
SRSF2 transcriptional function maintains genome integrity during cell divisionSemantic proximity
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancerSemantic proximity
SRSF3 Expression Serves as a Potential Biomarker for Prognostic and Immune Response in Pan-CancerSemantic proximity
Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.Semantic proximity
Post-transcriptional control of SRSF9 promotes the epithelial-to-mesenchymal transition (EMT) in colorectal cancer cellsSemantic proximity
An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.Semantic proximity
The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal CancerSemantic proximity
Differential expression profile of master regulators of gene expression- Serine-arginine rich splicing factor family in Oral CancerSemantic proximity
MIR17HG Expression Is Transcriptionally Regulated by PAX3::FOXO1 and MYCN and is Necessary for Oncogenic Activity in Fusion-Positive RhabdomyosarcomaSemantic proximity
Epigenetic CRISPR Screening of 9p21.3 Non-Coding Regions identifies Cis-Regulatory Elements of P16 <sup>INK4a</sup> and P15 <sup>INK4b</sup> Controlling Cellular SenescenceSemantic proximity
Select a neighboring publication to make it the new centre.