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Article

Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis.

Journal of dental research - 1 Oct 2017

Ries R J, Yu W, Holton N, Cao H, Amendt B A

Abstract excerpt

The role that noncoding regions of the genome play in the etiology of cleft palate is not well studied. A novel method of microRNA (miR) inhibition that allows for specific miR knockdown in vivo has been developed by our laboratory. To further understand the role of miRs in palatogenesis, we used a new mouse model to inhibit specific miRs within the miR-17-92 cluster. Transgenic mice expressing inhibitory...

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Source

Open in PubMed Open full text

Identifiers

PMID: 28662367
DOI: 10.1177/0022034517716915
PMCID: PMC5613877

Genes

TGFBR2
TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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