Article
Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.
Cancer research - 1 Nov 2023
Wang Yemin, Chen Shary Yuting, Ta Monica, Senz Janine, Tao Lan Valerie, Thornton Shelby, Tamvada Nirupama, Yang Winnie, Moscovitz Yana, Li Eunice, Guo Jingjie, Shen Cindy, Douglas J Maxwell, Ei-Naggar Amal M, Kommoss Felix K F, Underhill T Michael, Singh Naveena, Gilks C Blake, Morin Gregg B, Huntsman David G
Abstract excerpt
DICER1 is an RNase III enzyme essential for miRNA biogenesis through cleaving precursor-miRNA hairpins. Germline loss-of-function DICER1 mutations underline the development of DICER1 syndrome, a rare genetic disorder that predisposes children to cancer development in organs such as lung, gynecologic tract, kidney, and brain. Unlike classical tumor suppressors, the somatic "second hit" in DICER1...
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