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Article

Sertoli cell-specific ablation of miR-17-92 cluster significantly alters whole testis transcriptome without apparent phenotypic effects.

PloS one - 1 Jan 2018

Hurtado Alicia, Real Francisca M, Palomino Rogelio, Carmona Francisco David, Burgos Miguel, Jiménez Rafael, Barrionuevo Francisco J

Abstract excerpt

MicroRNAs are frequently organized into polycistronic clusters whose transcription is controlled by a single promoter. The miR-17-92 cluster is expressed in most embryonic and postnatal organs. It is a potent oncogene associated to several types of cancer and it is involved in several important developmental processes. In the testis, expression of the miR-17-92 cluster in the germ cells is necessary to maintain...

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Identifiers

PMID: 29795630
DOI: 10.1371/journal.pone.0197685
PMCID: PMC5967698

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