Article
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Genes & development - 1 Dec 2019
Labi Verena, Peng Siying, Klironomos Filippos, Munschauer Mathias, Kastelic Nicolai, Chakraborty Tirtha, Schoeler Katia, Derudder Emmanuel, Martella Manuela, Mastrobuoni Guido, Hernandez-Miranda Luis R, Lahmann Ines, Kocks Christine, Birchmeier Carmen, Kempa Stefan, Quintanilla-Martinez de Fend Leticia, Landthaler Markus, Rajewsky Nikolaus, Rajewsky Klaus
Abstract excerpt
Knockout of the ubiquitously expressed miRNA-17∼92 cluster in mice produces a lethal developmental lung defect, skeletal abnormalities, and blocked B lymphopoiesis. A shared target of miR-17∼92 miRNAs is the pro-apoptotic protein BIM, central to life-death decisions in mammalian cells. To clarify the contribution of miR-17∼92:Bim interactions to the complex miR-17∼92 knockout phenotype, we used a system of...
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