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Article

MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression.

Oncotarget - 30 May 2017

Quattrochi Brian, Gulvady Anushree, Driscoll David R, Sano Makoto, Klimstra David S, Turner Christopher E, Lewis Brian C

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterized by resistance to currently employed chemotherapeutic approaches. Members of the mir-17~92 cluster of microRNAs (miRNAs) are upregulated in PDAC, but the precise roles of these miRNAs in PDAC are unknown. Using genetically engineered mouse models, we show that loss of mir-17~92 reduces ERK pathway activation downstream of mutant KRAS and...

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Share to Carcinoma, Intraductal, Noninfiltrating
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Gene Knockout Techniques

Share to MAP Kinase Signaling System

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Source

Open in PubMed Open full text

Identifiers

PMID: 28415794
DOI: 10.18632/oncotarget.16277
PMCID: PMC5482626

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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