Article
Novel regulation and functional interaction of polycistronic miRNAs.
RNA (New York, N.Y.) - 1 Jan 2016
Truscott Mary, Islam Abul B M M K, Frolov Maxim V
Abstract excerpt
The importance of microRNAs in gene expression and disease is well recognized. However, what is less appreciated is that almost half of miRNA genes are organized in polycistronic clusters and are therefore coexpressed. The mir-11∼998 cluster consists of two miRNAs, miR-11 and miR-998. Here, we describe a novel layer of regulation that links the processing and expression of miR-998 to the presence of the mir-11...
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