Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin.

PLoS pathogens - 1 May 2015

Meyer Austin G, Wilke Claus O

Abstract excerpt

We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution. We consider three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), Immune Epitope Database (IEDB) epitope sites (as a proxy for host immune bias), and proximity to the receptor-binding region (as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Sialic Acids
Share to Antigens, Viral
Share to Epitope Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza, Human

Share to Protein Stability

Share to Solvents

Source

Open in PubMed Open full text

Identifiers

PMID: 26020774
DOI: 10.1371/journal.ppat.1004940
PMCID: PMC4447415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin.PMID 26020774Read ↗

Geometric constraints dominate the antigenic evolution of influenza H3N2 hemagglutininSemantic proximity Read ↗

Determination of antigenicity-altering patches on the major surface protein of human influenza A/H3N2 virusesSemantic proximity Read ↗

Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutininSemantic proximity Read ↗

Predictability of the antigenic evolution of human influenza A H3 virusesSemantic proximity Read ↗

Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans.Semantic proximity Read ↗

Inference of genotype-phenotype relationships in the antigenic evolution of human influenza A (H3N2) viruses.Semantic proximity Read ↗

Predictability of antigenic evolution for H3N2 human influenza A virus.Semantic proximity Read ↗

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutininSemantic proximity Read ↗

Integrating sequence variation and protein structure to identify sites under selection.Semantic proximity Read ↗

Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation.Semantic proximity Read ↗

Cross-species comparison of site-specific evolutionary-rate variation in influenza haemagglutinin.Semantic proximity Read ↗

Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.