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Article

Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation.

Scientific reports - 1 Jan 2011

Soundararajan Venkataramanan, Zheng Shu, Patel Neel, Warnock Ken, Raman Rahul, Wilson Ian A, Raguram S, Sasisekharan V, Sasisekharan Ram

Abstract excerpt

Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To understand this phenomenon, we computed the Significant Interactions Network (SIN) for each residue and mapped the networks of antigenic site residues on a representative H1N1 HA....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Source

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Identifiers

PMID: 22355715
DOI: 10.1038/srep00200
PMCID: PMC3242012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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