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Determination of antigenicity-altering patches on the major surface protein of human influenza A/H3N2 viruses

1 Jan 2016

Abstract excerpt

Human influenza viruses are rapidly evolving RNA viruses that cause short-term respiratory infections with substantial morbidity and mortality in annual epidemics. Uncovering the general principles of viral coevolution with human hosts is important for pathogen surveillance and vaccine design. Protein regions are an appropriate model for the interactions between two macromolecules, but the currently used epitope...

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PMID: 27774294
DOI: 10.1093/ve/vev025

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