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Article

Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans.

PLoS computational biology - 1 Jun 2020

Saad-Roy Chadi M, Arinaminpathy Nimalan, Wingreen Ned S, Levin Simon A, Akey Joshua M, Grenfell Bryan T

Abstract excerpt

Seasonal influenza A viruses of humans evolve rapidly due to strong selection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface protein. Based on mouse transmission experiments, a proposed mechanism for immune evasion consists of increased avidity to host cellular receptors, mediated by electrostatic charge interactions with negatively charged cell surfaces. In support of...

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PMID: 32584807
DOI: 10.1371/journal.pcbi.1007892
PMCID: PMC7316228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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