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Article

Integrating sequence variation and protein structure to identify sites under selection.

Molecular biology and evolution - 1 Jan 2013

Meyer Austin G, Wilke Claus O

Abstract excerpt

We present a novel method to identify sites under selection in protein-coding genes. Our method combines the traditional Goldman-Yang model of coding-sequence evolution with the information obtained from the 3D structure of the evolving protein, specifically the relative solvent accessibility (RS...

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Identifiers

PMID: 22977116
DOI: 10.1093/molbev/mss217
PMCID: PMC3525147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22977116-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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