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Article

Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape.

Nature communications - 6 Mar 2020

Wu Nicholas C, Otwinowski Jakub, Thompson Andrew J, Nycholat Corwin M, Nourmohammad Armita, Wilson Ian A

Abstract excerpt

Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile evolvability. However, HA antigenic site B, which has become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily constrained by its involvement in receptor binding. Here, we employ deep mutational scanning to probe the local fitness landscape of HA antigenic site B in six different human H3N2 strains spanning from...

Topics

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Antigens, Viral
Crystallography, X-Ray
Dogs
Hemagglutinin Glycoproteins, Influenza Virus
Influenza A Virus, H3N2 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Madin Darby Canine Kidney Cells

Protein Domains

Receptors, Cell Surface

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Identifiers

PMID: 32144244
DOI: 10.1038/s41467-020-15102-5
PMCID: PMC7060233

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