Article

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutinin

2026-07-22

Abstract excerpt

The antigenic drift of viral glycoproteins must be balanced by purifying selection pressure to maintain functionality. Understanding these evolutionary processes is key to predicting and combating viral evolution but is primarily based on influenza A(H3N2), which may limit generalisability. By characterising the influenza B virus haemagglutinin (HA) over 8 decades of circulation in humans, we found continuous gene...

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Literature Corpus work: cc2be441-8e94-57b6-a7bc-a30d5bd09a40
DOI: 10.64898/2026.07.22.739994

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