Article
Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes.
PLoS genetics - 1 May 2015
Lada Artem G, Kliver Sergei F, Dhar Alok, Polev Dmitrii E, Masharsky Alexey E, Rogozin Igor B, Pavlov Youri I
Abstract excerpt
Mutations in genomes of species are frequently distributed non-randomly, resulting in mutation clusters, including recently discovered kataegis in tumors. DNA editing deaminases play the prominent role in the etiology of these mutations. To gain insight into the enigmatic mechanisms of localized hypermutagenesis that lead to cluster formation, we analyzed the mutational single nucleotide variations (SNV) data...
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