Article
APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.
Genome research - 1 Feb 2016
Seplyarskiy Vladimir B, Soldatov Ruslan A, Popadin Konstantin Y, Antonarakis Stylianos E, Bazykin Georgii A, Nikolaev Sergey I
Abstract excerpt
APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA). A fraction of the APOBEC-induced mutations occur as clusters ("kataegis") in single-stranded DNA produced during repair of double-stranded breaks (DSBs). However, the properties of the remaining 87% of nonclustered...
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