Molecular origins of APOBEC-associated mutations in cancer.

Abstract excerpt

The APOBEC family of cytidine deaminases has been proposed to represent a major enzymatic source of mutations in cancer. Here, we summarize available evidence that links APOBEC deaminases to cancer mutagenesis. We also highlight newly identified human cell models of APOBEC mutagenesis, including cancer cell lines with suspected endogenous APOBEC activity and a cell system of telomere crisis-associated mutations....

Topics

• APOBEC Deaminases
• Animals
• Humans
• Mutagenesis
• Mutation
• Neoplasms