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Article

Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.

PLoS genetics - 1 Jan 2013

Lada Artem G, Stepchenkova Elena I, Waisertreiger Irina S R, Noskov Vladimir N, Dhar Alok, Eudy James D, Boissy Robert J, Hirano Masayuki, Rogozin Igor B, Pavlov Youri I

Abstract excerpt

Genetic information should be accurately transmitted from cell to cell; conversely, the adaptation in evolution and disease is fueled by mutations. In the case of cancer development, multiple genetic changes happen in somatic diploid cells. Most classic studies of the molecular mechanisms of mutagenesis have been performed in haploids. We demonstrate that the parameters of the mutation process are different in...

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Identifiers

PMID: 24039593
DOI: 10.1371/journal.pgen.1003736
PMCID: PMC3764175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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