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Article

AID/APOBEC cytosine deaminase induces genome-wide kataegis.

Biology direct - 18 Dec 2012

Lada Artem G, Dhar Alok, Boissy Robert J, Hirano Masayuki, Rubel Aleksandr A, Rogozin Igor B, Pavlov Youri I

Abstract excerpt

UNLABELLED: Clusters of localized hypermutation in human breast cancer genomes, named "kataegis" (from the Greek for thunderstorm), are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kataegis is still lacking. We have sequenced the genomes of yeast mutants induced in diploids by expression of the gene for PmCDA1, a...

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Identifiers

PMID: 23249472
DOI: 10.1186/1745-6150-7-47
PMCID: PMC3542020

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AID/APOBEC cytosine deaminase induces genome-wide kataegis.PMID 23249472Read ↗

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