Clusters of Multiple Mutations: Incidence and Molecular Mechanisms.

Abstract excerpt

It has been long understood that mutation distribution is not completely random across genomic space and in time. Indeed, recent surprising discoveries identified multiple simultaneous mutations occurring in tiny regions within chromosomes while the rest of the genome remains relatively mutation-free. Mechanistic elucidation of these phenomena, called mutation showers, mutation clusters, or kataegis, in parallel...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Repair
• Share to DNA, Single-Stranded
• Share to Mice, Mutant Strains