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Article

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

Nature genetics - 1 Sept 2013

Roberts Steven A, Lawrence Michael S, Klimczak Leszek J, Grimm Sara A, Fargo David, Stojanov Petar, Kiezun Adam, Kryukov Gregory V, Carter Scott L, Saksena Gordon, Harris Shawn, Shah Ruchir R, Resnick Michael A, Getz Gad, Gordenin Dmitry A

Abstract excerpt

Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may induce mutation clusters in human tumors. We show here that throughout cancer genomes APOBEC-mediated mutagenesis is pervasive and correlates with APOBEC mRNA levels. Mutation clusters in whole-genome and exome data sets conformed to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23852170
DOI: 10.1038/ng.2702
PMCID: PMC3789062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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