Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes.

eLife - 19 Sept 2014

Taylor Benjamin J M, Wu Yee Ling, Rada Cristina

Abstract excerpt

Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as kataegis. It remains unclear how deaminases access double stranded genomes and whether off-target mutations favor certain loci, although transcription and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-3G Deaminase
Share to Cytidine Deaminase
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Promoter Regions, Genetic

Share to RNA, Fungal

Share to Saccharomyces cerevisiae

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 25237741
DOI: 10.7554/eLife.03553
PMCID: PMC4359381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes.PMID 25237741Read ↗

The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.Semantic proximity Read ↗

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes.Semantic proximity Read ↗

Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.Semantic proximity Read ↗

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA SubstratesSemantic proximity Read ↗

Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex.Semantic proximity Read ↗

Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNASemantic proximity Read ↗

Creative deaminases, self-inflicted damage, and genome evolution.Semantic proximity Read ↗

The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences.Semantic proximity Read ↗

A licensing step links AID to transcription elongation for mutagenesis in B cells.Semantic proximity Read ↗

Defining APOBEC-induced mutation signatures and modifying activities in yeast.Semantic proximity Read ↗

Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.Semantic proximity Read ↗

The AID/APOBEC family of nucleic acid mutatorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.