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High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?

Mutation research - 1 Jun 2015

Maslov Alexander Y, Quispe-Tintaya Wilber, Gorbacheva Tatyana, White Ryan R, Vijg Jan

Abstract excerpt

The advent of next generation sequencing (NGS) technology has provided the means to directly analyze the genetic material in primary cells or tissues of any species in a high throughput manner for mutagenic effects of potential genotoxic agents. In principle, direct, genome-wide sequencing of human primary cells and/or tissue biopsies would open up opportunities to identify individuals possibly exposed to...

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PMID: 25934519
DOI: 10.1016/j.mrfmmm.2015.03.014
PMCID: PMC4532622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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