Article

DNA damage is a major cause of sequencing errors, directly confounding variant identification

2016-08-19

Abstract excerpt

Pervasive mutations in somatic cells generate a heterogeneous genomic population within an organism and may result in serious medical conditions. While cancer is the most studied disease associated with somatic variations, recent advances in single cell and ultra deep sequencing indicate that a number of phenotypes and pathologies are impacted by cell specific variants. Currently, the accurate identification of lo...

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Literature Corpus work: f8813084-212f-5103-9468-c8d617ba0cea
DOI: 10.1101/070334

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