Article
In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?
Environmental and molecular mutagenesis - 1 Jan 2020
Godschalk Roger W L, Yauk Carole L, van Benthem Jan, Douglas George R, Marchetti Francesco
Abstract excerpt
In utero development represents a sensitive window for the induction of mutations. These mutations may subsequently expand clonally to populate entire organs or anatomical structures. Although not all adverse mutations will affect tissue structure or function, there is growing evidence that clonally expanded genetic mosaics contribute to various monogenic and complex diseases, including cancer. We posit that...
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