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Article

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.

Molecular cell - 7 May 2015

Hellmuth Susanne, Rata Scott, Brown Andreas, Heidmann Stefan, Novak Bela, Stemmann Olaf

Abstract excerpt

Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit by separase triggers chromosome segregation in anaphase. Vertebrate separase is held inactive by mutually exclusive binding to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent degradation of these regulators. Although most separase is usually found in association with securin, this anaphase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25921067
DOI: 10.1016/j.molcel.2015.03.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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