Article

Deregulation of Chromosome Segregation and Cancer

2019-11-22

Abstract excerpt

The mitotic spindle assembly checkpoint (SAC) is an intricate cell signaling system that ensures the high fidelity and timely segregation of chromosomes during cell division. Mistakes in this process can lead to the loss, gain, or rearrangement of the genetic material. Gross chromosomal aberrations are usually lethal but can cause birth and development defects as well as cancer. Despite advances in the identificat...

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Literature Corpus work: 628c2b90-1114-5221-90ff-0ce4f30bb2b0
DOI: 10.1146/annurev-cancerbio-030419-033541

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