Article
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.
Science (New York, N.Y.) - 17 Aug 2001
Hauf S, Waizenegger I C, Peters J M
Abstract excerpt
Cell division depends on the separation of sister chromatids in anaphase. In yeast, sister separation is initiated by cleavage of cohesin by the protease separase. In vertebrates, most cohesin is removed from chromosome arms by a cleavage-independent mechanism. Only residual amounts of cohesin are cleaved at the onset of anaphase, coinciding with its disappearance from centromeres. We have identified two separase...
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