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Article

Mutual inhibition of separase and Cdk1 by two-step complex formation.

Molecular cell - 1 Jul 2005

Gorr Ingo H, Boos Dominik, Stemmann Olaf

Abstract excerpt

Stable maintenance of genetic information requires chromosome segregation to occur with high accuracy. Anaphase is triggered when ring-shaped cohesin is cleaved by separase, a protease regulated by association with its inhibitor securin. Dispensability of vertebrate securin strongly suggests additional means of separase regulation. Indeed, sister chromatid separation but not securin degradation is inhibited by...

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Identifiers

PMID: 15989971
DOI: 10.1016/j.molcel.2005.05.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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