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Article

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.

PLoS genetics - 1 Mar 2018

Lianga Noel, Doré Carole, Kennedy Erin K, Yeh Elaine, Williams Elizabeth C, Fortinez Camille Marie, Wang Alick, Bloom Kerry S, Rudner Adam D

Abstract excerpt

Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically links sister chromatids, triggering sister chromatid separation. Separase is regulated by the degradation of the anaphase inhibitor Securin which liberates Separase from inhibitory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29561844
DOI: 10.1371/journal.pgen.1007029
PMCID: PMC5880407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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