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Article

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.

Nature communications - 14 Jul 2021

Thomas Christopher, Wetherall Benjamin, Levasseur Mark D, Harris Rebecca J, Kerridge Scott T, Higgins Jonathan M G, Davies Owen R, Madgwick Suzanne

Abstract excerpt

Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes together. Securin must be depleted before anaphase to ensure chromosome segregation occurs with anaphase. Here we find that in meiosis I, mouse oocytes contain an excess of securin over separase. We reveal a mechanism that promotes excess...

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Identifiers

PMID: 34262048
DOI: 10.1038/s41467-021-24554-2
PMCID: PMC8280194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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