Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.

Genes & development - 15 Sept 2002

Herzig Alf, Lehner Christian F, Heidmann Stefan

Abstract excerpt

Sister-chromatid separation in mitosis requires proteolytic cleavage of a cohesin subunit. Separase, the corresponding protease, is activated at the metaphase-to-anaphase transition. Activation involves proteolysis of an inhibitory subunit, securin, following ubiquitination mediated by the anaphase-promoting complex/cyclosome. In Drosophila, the securin PIM associates not only with separase (SSE), but also with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Anaphase
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Drosophila Proteins

Share to Endopeptidases

Share to Insect Proteins

Share to Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 12231632
DOI: 10.1101/gad.242202
PMCID: PMC187444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.PMID 12231632Read ↗

Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation.Semantic proximity Read ↗

Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.Semantic proximity Read ↗

Mutual inhibition of separase and Cdk1 by two-step complex formation.Semantic proximity Read ↗

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.Semantic proximity Read ↗

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.Semantic proximity Read ↗

Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.Semantic proximity Read ↗

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.Semantic proximity Read ↗

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.Semantic proximity Read ↗

The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin.Semantic proximity Read ↗

Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.Semantic proximity Read ↗

Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons.Semantic proximity Read ↗

Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.