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Article

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Cell reports - 18 Oct 2016

Brieño-Enríquez Miguel A, Moak Stefannie L, Toledo Melissa, Filter Joshua J, Gray Stephen, Barbero José L, Cohen Paula E, Holloway J Kim

Abstract excerpt

Mammalian NIMA-like kinase-1 (NEK1) is a dual-specificity kinase highly expressed in mouse germ cells during prophase I of meiosis. Loss of NEK1 induces retention of cohesin on chromosomes at meiotic prophase I. Timely deposition and removal of cohesin is essential for accurate chromosome segregation. Two processes regulate cohesin removal: a non-proteolytic mechanism involving WAPL, sororin, and PDS5B and direct...

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Share to Chromatids
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Cohesins

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Share to Mice, Mutant Strains

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Source

Open in PubMed Open full text

Identifiers

PMID: 27760328
DOI: 10.1016/j.celrep.2016.09.059
PMCID: PMC5123770

Genes

NEK1
WAPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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