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Article

Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.

The Journal of biological chemistry - 24 Aug 2007

Holland Andrew J, Böttger Franziska, Stemmann Olaf, Taylor Stephen S

Abstract excerpt

The onset of anaphase is triggered by the activation of a site-specific protease called separase. Separase cleaves the chromosomal cohesins holding the duplicated sister chromatids together, allowing sisters to simultaneously separate and segregate to opposite ends of the cell before division. Ac...

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Identifiers

PMID: 17604273
DOI: 10.1074/jbc.M702545200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17604273-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.PMID 17604273Read ↗

Mutual inhibition of separase and Cdk1 by two-step complex formation.Semantic proximity Read ↗

Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.Semantic proximity Read ↗

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.Semantic proximity Read ↗

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.Semantic proximity Read ↗

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.Semantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

The Dual Mechanism of Separase Regulation by SecurinSemantic proximity Read ↗

Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.Semantic proximity Read ↗

Structure and function of the PP2A-shugoshin interaction.Semantic proximity Read ↗

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.Semantic proximity Read ↗

Studies on substrate recognition by the budding yeast separase.Semantic proximity Read ↗

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.Semantic proximity Read ↗

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