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Article

Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.

Molecular pharmacology - 1 Jul 2015

Chen Eugene C, Liang Xiaomin, Yee Sook Wah, Geier Ethan G, Stocker Sophie L, Chen Ligong, Giacomini Kathleen M

Abstract excerpt

Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3 (OCT3, SLC22A3), expressed ubiquitously, transports metformin, but its in vivo role in metformin response is not known. Using Oct3 knockout mice, the role of the transporter in metformin pharmacokinetics...

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Identifiers

PMID: 25920679
DOI: 10.1124/mol.114.096776
PMCID: PMC4468641

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