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Article

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Hepatology (Baltimore, Md.) - 1 Oct 2009

Nies Anne T, Koepsell Hermann, Winter Stefan, Burk Oliver, Klein Kathrin, Kerb Reinhold, Zanger Ulrich M, Keppler Dietrich, Schwab Matthias, Schaeffeler Elke

Abstract excerpt

UNLABELLED: An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations and are taken up by organic cation transporters (OCTs) of the solute carrier family 22 (SLC22). Because interindividual variability of OCT expression may affect response to cationic drugs such as metformin, we systematically investigated genetic and nongenetic factors of...

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PMID: 19591196
DOI: 10.1002/hep.23103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.PMID 19591196Read ↗

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