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Article

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

Pharmacogenetics and genomics - 1 Nov 2010

Chen Ligong, Pawlikowski Bradley, Schlessinger Avner, More Swati S, Stryke Doug, Johns Susan J, Portman Michael A, Chen Eugene, Ferrin Thomas E, Sali Andrej, Giacomini Kathleen M

Abstract excerpt

OBJECTIVES: The goals of this study were to determine the role of organic cation transporter 3 (OCT3) in the pharmacological action of metformin and to identify and functionally characterize genetic variants of OCT3 with respect to the uptake of metformin and monoamines. METHODS: For pharmacologi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20859243
DOI: 10.1097/FPC.0b013e32833fe789
PMCID: PMC2976715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20859243-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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