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Article

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.

Handbook of experimental pharmacology - 1 Jan 2011

Nies Anne T, Koepsell Hermann, Damme Katja, Schwab Matthias

Abstract excerpt

Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and efflux transporters, respectively, for xenobiotics including several clinically used drugs such as the antidiabetic agent metformin, the antiviral agent lamivudine, and the anticancer drug oxaliplatin. Expression of human OCT1...

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PMID: 21103969
DOI: 10.1007/978-3-642-14541-4_3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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