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Article

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.

Diabetes - 1 May 2015

Dujic Tanja, Zhou Kaixin, Donnelly Louise A, Tavendale Roger, Palmer Colin N A, Pearson Ewan R

Abstract excerpt

Metformin is the most widely prescribed medication for the treatment of type 2 diabetes (T2D). However, gastrointestinal (GI) side effects develop in ~25% of patients treated with metformin, leading to the discontinuation of therapy in ~5% of cases. We hypothesized that reduced transport of metformin via organic cation transporter 1 (OCT1) could increase metformin concentration in the intestine, leading to...

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Identifiers

PMID: 25510240
DOI: 10.2337/db14-1388
PMCID: PMC4452716

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Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.PMID 25510240Read ↗

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