Article
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
Pharmacogenetics and genomics - 1 Jul 2009
Chen Ying, Li Shuanglian, Brown Chaline, Cheatham Stephen, Castro Richard A, Leabman Maya K, Urban Thomas J, Chen Ligong, Yee Sook Wah, Choi Ji Ha, Huang Yong, Brett Claire M, Burchard Esteban G, Giacomini Kathleen M
Abstract excerpt
OBJECTIVE: The goal of this study was to determine the effect of a genetic variant in the organic cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S, on the pharmacokinetics of the antidiabetic drug, metformin. METHODS: The uptake of metformin was performed in stably transfected HEK-293 cells expressing the empty vector (MOCK), the reference OCT2-808G, and the variant...
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