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Article

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

The Journal of clinical investigation - 1 May 2007

Shu Yan, Sheardown Steven A, Brown Chaline, Owen Ryan P, Zhang Shuzhong, Castro Richard A, Ianculescu Alexandra G, Yue Lin, Lo Joan C, Burchard Esteban G, Brett Claire M, Giacomini Kathleen M

Abstract excerpt

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is unknown. Recent studies have shown that human OCT1 is highly polymorphic. We investigated whether OCT1 plays a role in...

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Identifiers

PMID: 17476361
DOI: 10.1172/JCI30558
PMCID: PMC1857259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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